Peptide Gelling & Clouding Research Guide: Solubility Solutions
Overview Newly reconstituted peptides occasionally appear cloudy, gelatinous, or particulate in aqueous buffer. Researchers unfamiliar with peptide chemistry sometimes interpret this as a quality defect on the lyophilized starting material. In most cases, the appearance reflects normal aggregation behavior of peptides rich in hydrophobic amino acid residues when those peptides are introduced to a neutral…


