Melanotan-2 10mg

Melanotan-II (MT-2) 10mg Peptide

Melanotan-II (MT-2) is a synthetic cyclic heptapeptide analog of α-melanocyte-stimulating hormone (α-MSH). In modern preclinical literature, it is widely utilized as a potent, nonselective agonist at several melanocortin receptor subtypes (MC1R, MC3R, MC4R, and MC5R). For investigators looking to order melanotan compounds for their laboratory, this specific peptide allows researchers to explore the expansive melanocortin system, which regulates physiological processes ranging from melanogenesis to energy homeostasis.

For researchers searching to buy melanotan 2 in a stabilized format, Protide Health supplies this compound as a highly purified, lyophilized powder. Designed to cross the blood-brain barrier in in vivo models, the MT-2 peptide provides a precise molecular tool for investigating central and peripheral neuroendocrine signaling pathways.

Peptide Type: Synthetic α-MSH Analog (Melanocortin Receptor Agonist)
Vial Content: 10mg Melanotan-II (MT-2)
Form: Lyophilized (Freeze-Dried) for maximum biochemical stability

Technical Overview: Molecular Structure and Stability

Melanotan-II was originally engineered to address the rapid enzymatic degradation of endogenous α-MSH. Its sequence (Ac-Nle-Asp-His-D-Phe-Arg-Trp-Lys-NH₂) features a unique cyclic conformation. In laboratory settings, this cyclic design significantly prolongs the research-ready stability of the compound, offering a more robust half-life compared to linear analogs.

Receptor Affinity Profile

MT-2 is heavily studied for its unique binding profile. It binds with high potency to MC1R and MC4R, and moderate affinity at MC3R and MC5R. Crucially, it exhibits minimal MC2R activity, meaning researchers can utilize it in models without triggering unwanted adrenal stimulation.

Pharmacokinetics & Tissue Penetration

In preclinical rodent models, Melanotan-II demonstrates measurable activity across both peripheral and central tissues. Because it effectively penetrates the central nervous system (CNS), it is heavily utilized in models mapping hypothalamic circuits alongside peripheral skin melanocyte assays.

Mechanism of Action: Melanocortin Receptor Signaling

Researchers who source melanotan-2 peptide for sale utilize it to map specific receptor-mediated outcomes. The peptide’s mechanisms of action are thoroughly documented in preclinical literature.

1. Melanogenesis and MC1R Activation

Through the activation of MC1R, Melanotan-II stimulates isolated melanocytes to upregulate eumelanin production. Animal models utilize this mechanism to investigate cellular resistance to UV-induced DNA damage, providing a framework for studying photoprotection and pigment-related cellular mechanisms.

2. Energy Homeostasis via MC3R and MC4R

In rodent studies mapping hypothalamic melanocortin signaling, MT-2 administration is observed suppressing orexigenic neuropeptide Y (NPY) pathways. This neuroendocrine circuitry provides a highly reliable model for researchers studying the complex mechanisms of metabolic regulation and feeding behavior.

3. Neuroendocrine Modulation & CNS Pathways

Early preclinical in vivo studies demonstrated that MC4R activation in the CNS influences neuroendocrine signaling pathways related to arousal. This makes MT-2 a primary model compound for studying complex reproductive endocrinology and systemic neurological responses.

4. Cytokine Modulation and Immune Signaling

Researchers utilize MT-2 to investigate melanocortin receptor-mediated cytoprotection. In cell and animal models, the peptide suppresses pro-inflammatory cytokines (such as TNF-α and IL-6) while promoting anti-inflammatory IL-10. This pathway is heavily researched for its potential involvement in NF-κB inhibition and systemic immune regulation.

Specifications Table: Melanotan-II

Where can I find Melanotan 2 for sale online?

Qualified researchers looking to buy melanotan 2 online can acquire it directly through Protide Health. We provide high-purity melanotan 2 10mg vials explicitly manufactured for in vitro and animal modeling. Every batch is third-party tested via HPLC to ensure exact molecular weight and >99% purity.

What is the Melanotan 2 half life in research models?

Due to its cyclic conformation, the melanotan 2 half life in standard rodent in vivo models is significantly extended compared to endogenous α-MSH, typically measuring between 1 to 2 hours. This prolonged stability allows researchers a wider observational window during pharmacokinetic assays.

Is Melanotan 2 FDA approved?

No. When researchers ask if melanotan 2 is FDA approved, the answer is no. While similar compounds (like afamelanotide) have navigated clinical approval pathways for specific conditions, Melanotan-II (MT-2) remains strictly an investigational compound. It is not approved for human consumption, therapeutic use, or cosmetic application.

Why do laboratories buy mt-2 10mg vials instead of smaller sizes?

The mt-2 10mg for sale in our catalog provides researchers with the optimal volume required to run comprehensive, dose-dependent assays. Rather than continuously reordering smaller batches, the 10mg size allows a laboratory to standardize their entire study across a single, uniform lot, ensuring strict control over experimental variables.

Conclusion: Summary for Researchers

Melanotan-II is a potent, cyclic analog of α-MSH with broad agonist activity across multiple melanocortin receptor subtypes. By engaging both peripheral and central receptors (MC1R-MC5R), it provides a multifaceted platform for exploring the intersection of melanogenesis, energy homeostasis, immune modulation, and neuroendocrine signaling. Available exclusively for laboratory use, this highly stable peptide is a versatile and indispensable tool for advancing preclinical melanocortin biology.

Citations

Hadley ME et al., 1999. Discovery and characterization of melanocortin peptides and analogs. Annals of the New York Academy of Sciences.

Fan W et al., 1997. Role of melanocortinergic neurons in behavioral models. Nature.

Hruby VJ et al., 1995. Design of cyclic melanotropin analogs with increased potency. Peptides.

Mountjoy KG, 2010. Melanocortin receptors: physiology and pharmacology. Pharmacological Reviews.

Legal Disclaimer

Melanotan-II (MT-2) is intended for laboratory research purposes only. It is not approved by the U.S. Food and Drug Administration (FDA) or any regulatory authority for human consumption, medical use, or therapeutic application. It is intended solely for investigational use in controlled laboratory settings by qualified researchers. Protide Health does not endorse or promote the use of Melanotan-II in humans or animals outside of approved research protocols. Researchers must comply with all applicable local, state, and federal regulations, including obtaining necessary approvals for experimental use.