Selank 11mg: Anxiety Relief & Mood Support

What is Selank?

Selank is a synthetic heptapeptide developed by the Institute of Molecular Genetics of the Russian Academy of Sciences. Its sequence is Thr-Lys-Pro-Arg-Pro-Gly-Pro, with a molecular weight of approximately 751.9 g/mol. Derived from the endogenous tetrapeptide tuftsin (Thr-Lys-Pro-Arg), Selank is stabilized by the addition of a Gly-Pro-Pro tail to resist enzymatic degradation. It is a water-soluble peptide designed to target the central nervous system (CNS), crossing the blood-brain barrier effectively. Selank is typically administered via intranasal spray (e.g., 200-750 mcg/day, 1-3 drops per nostril) or subcutaneous injection (e.g., 100-500 mcg/day) in research and clinical settings. Developed in Russia, it is used for anxiolytic and nootropic effects, available as a prescription drug in some countries (e.g., Russia, Ukraine) or as a research chemical elsewhere, and is under investigation for stress-related disorders and cognitive enhancement.

Mechanism of Action

Selank’s primary mechanism involves modulating neurotransmitter systems and stress responses, particularly in the brain, through the following processes:

GABA System Modulation: Selank enhances GABA receptor activity indirectly, increasing inhibitory neurotransmission and reducing anxiety, similar to benzodiazepines but without sedation or dependence.

BDNF Upregulation: It increases brain-derived neurotrophic factor (BDNF) expression in the hippocampus, promoting neuroplasticity, memory formation, and stress resilience.

Enkephalin Stabilization: Selank inhibits enkephalin-degrading enzymes (e.g., carboxypeptidase), elevating endogenous opioid levels, which contribute to anxiolytic and mood-enhancing effects.

Monoamine Regulation: It modulates serotonin, dopamine, and norepinephrine levels, accelerating their turnover in the brain (e.g., hypothalamus, hippocampus) to improve mood and cognitive function under stress.

Anti-Stress Effects: Reduces cortisol and adrenocorticotropic hormone (ACTH) release by normalizing hypothalamic-pituitary-adrenal (HPA) axis activity, mitigating stress-induced physiological changes.

Immune Modulation: Exhibits mild immunomodulatory effects by upregulating IL-6 and balancing T-helper cell responses, potentially aiding stress-related immune suppression.

Selank’s specificity for stress and cognitive modulation, without sedative or addictive properties, distinguishes it from traditional anxiolytics.

Benefits

Selank’s benefits, supported by preclinical and clinical studies, include:

Anxiety Reduction: Rapidly alleviates anxiety symptoms in humans and animals, comparable to mild benzodiazepines, without impairing cognition.

Cognitive Enhancement: Improves memory, attention, and learning capacity, particularly under stress, via BDNF and neurotransmitter effects.

Stress Resilience: Protects against stress-induced behavioral and physiological damage, normalizing HPA axis function.

Mood Improvement: Elevates mood and reduces depressive-like behaviors in preclinical models by balancing monoamines and enkephalins.

Neuroprotection: Supports neuronal survival and plasticity, potentially aiding recovery from brain injury or chronic stress.

Immune Support: Enhances immune responses under stress, reducing susceptibility to infections in animal models.

These benefits position Selank as a versatile peptide for mental health and cognitive performance.

Use Cases

Selank is used clinically in some regions and experimentally elsewhere, with applications including:

Anxiety Disorders: Prescribed for generalized anxiety disorder (GAD) and stress-related anxiety (e.g., 200-450 mcg/day intranasal) in Russia.

Cognitive Enhancement: Investigated for memory and focus improvement in healthy individuals or those under stress (e.g., 300 mcg/day).

Stress Management: Used to mitigate acute and chronic stress effects (e.g., 100-500 mcg/day SC or intranasal) in preclinical and clinical settings.

Mood Disorders: Explored for mild depression or emotional instability in research models.

Neurological Conditions: Studied for potential in traumatic brain injury (TBI) recovery and neurodegenerative disease support (e.g., 5-10 mg/kg in rats).

Administration typically involves intranasal drops or injections, with dosing tailored to condition severity or research protocols.

Research Studies

Below is a summary of key studies on Selank, focusing on its mechanisms and benefits:

Seredenin et al. (1998) - Bulletin of Experimental Biology and Medicine Demonstrated Selank reduces anxiety in rats (0.1-1 mg/kg) via GABA modulation, without sedative effects.

Kozlovskaya et al. (2003) - Neuroscience and Behavioral Physiology Showed Selank (300 mcg/day intranasal) improves memory and attention in stressed rats, linked to BDNF upregulation.

Semenova et al. (2010) - Bulletin of Experimental Biology and Medicine Reported Selank (0.3 mg/kg) normalizes enkephalin levels and reduces stress-induced behavioral deficits in rats.

Zozulya et al. (2008) - Bulletin of Experimental Biology and Medicine Found Selank (200-450 mcg/day intranasal) reduces anxiety in 62 GAD patients over 14 days, comparable to benzodiazepines but safer.

Uchakina et al. (2008) - Journal of Molecular Neuroscience Indicated Selank upregulates IL-6 and modulates immunity in stressed mice, enhancing antiviral responses.

Kolomin et al. (2014) - Advances in Experimental Medicine and Biology Showed Selank (0.15 mg/kg) enhances serotonin turnover and mood in rats under chronic stress.

These studies highlight Selank’s anxiolytic and nootropic potential, with ongoing research refining its applications.

Considerations

Safety: Well-tolerated in trials, with minimal side effects (e.g., mild nasal irritation); long-term human data beyond weeks are limited.

Regulation: Approved in Russia and Ukraine as a nasal spray; available as a research chemical elsewhere, not FDA-approved.

Evidence: Strong preclinical and Russian clinical support; broader human data are sparse, requiring further validation outside Eastern Europe.

In conclusion, Selank is a synthetic peptide with significant potential to reduce anxiety, enhance cognition, and improve stress resilience by modulating neurotransmitter and neurotrophic systems. Its efficacy in preclinical and limited clinical studies makes it a compelling candidate, though further global research is needed to solidify its therapeutic role. Consult a healthcare provider before use.

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For Research Use Only. Not For Human Consumption.